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Study on the levels of IFN-γ and IL-4 in patients with condyloma acuminatum

Yongjian Shi

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Abstract

Objective: To study the roles of IFN-γ and IL-4 in the pathogenesis of condyloma acuminatum(CA). Methods: The means of RT-PCR was taken to detect the expression of IFN-γ mRNA and IL-4 mRNA of the peripheral blood mononuclear cells (PBMC) of 42 patients with CA. Results: The results showed that the expression of IFN-γ mRNA in CA with short course was significantly higher than that of normal controls and CA with long course ( P 0.05); The expression of IL-4 mRNA in CA with long course was significantly higher than that of normal controls and CA with short course ( P 0.05). Conclusion: These data indicate that the expression of Th2-associated cytokine (IL-4) is predominant in patients of CA with long course. Increased expression of Th2-associated cytokine and decreased expression of Th1-associated cytokine may play an important role in the pathogenesis of recurrent CA.

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What this paper is about

Objective: To study the roles of IFN-γ and IL-4 in the pathogenesis of condyloma acuminatum(CA). Methods: The means of RT-PCR was taken to detect the expression of IFN-γ mRNA and IL-4 mRNA of the peripheral blood mononuclear cells (PBMC) of 42 patients with CA. Results: The results showed that the expression of IFN-γ mRNA in CA with short course was significantly higher than that of normal controls and CA with long course ( P 0.05); The expression of IL-4 mRNA in CA with long course was significantly higher than that of normal controls and CA with short course ( P 0.05). Conclusion: These data indicate that the expression of Th2-associated cytokine (IL-4) is predominant in patients of CA with long course. Increased expression of Th2-associated cytokine and decreased expression of Th1-associated cytokine may play an important role in the pathogenesis of recurrent CA.

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Available abstract

Objective: To study the roles of IFN-γ and IL-4 in the pathogenesis of condyloma acuminatum(CA). Methods: The means of RT-PCR was taken to detect the expression of IFN-γ mRNA and IL-4 mRNA of the peripheral blood mononuclear cells (PBMC) of 42 patients with CA. Results: The results showed that the expression of IFN-γ mRNA in CA with short course was significantly higher than that of normal controls and CA with long course ( P 0.05); The expression of IL-4 mRNA in CA with long course was significantly higher than that of normal controls and CA with short course ( P 0.05). Conclusion: These data indicate that the expression of Th2-associated cytokine (IL-4) is predominant in patients of CA with long course. Increased expression of Th2-associated cytokine and decreased expression of Th1-associated cytokine may play an important role in the pathogenesis of recurrent CA.

Key concepts: Condyloma Acuminatum, Peripheral blood mononuclear cell, Pathogenesis, Cytokine, Messenger RNA, Immunology, Medicine, Gene expression

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