The relationship between polymorphism of angiotensin II type 1 receptor gene and essential hypertension

Objective To investigate the relationship between polymorphism of angiotensin Ⅱ type 1 receptor (AT1R) gene and essential hypertension (EH), and the association between the AT1R gene polymorphism and plasm lipid level and LVMI (left ventricular mass index) were also studied. Methods 328 EH patients are collected as EH group, with 571 healthy people as control group. Polymerase chain reaction combined with restriction enzyme digestion was used to determine the polymorphism of the 1166 site of AT1R gene. Results The frequency of AC genotype in male EH group was higher than that in control group (0.239 vs 0.086, P0.001), with OR value 3.49 (95% CI=1.226-5.899). The frequencies of AC genotype and C1166 allele of AT1R gene in female EH patients were also higher than that in control group, but there was no statistical significance. Logistic regression analysis showed that age, gender, and family history of EH were independent risk factors of EH. Polymorphism of the gene failed to enter the model. There was linear relation between SBP and LVMI. Conclusion A1166C polymorphism of AT1R gene was related with EH and C1166 allele of AT1R gene may play a role in essential hypertension in males. However, it is not an independent risk factor for EH. There was no association between AT1R gene polymorphism and LVMI. The contribution of AT1R gene to the development of EH was independent of plasma lipid levels.