Correlations of AT_1R Gene Polymorphism to Cerebrovascular Diseases in Essential Hypertensive Patients

Objective: To investigate the association of angiotensinⅡ typeⅠreceptor (AT1R) gene polymorphism with cerebrovascu-lar diseases in essential hypertensive patients. Methods: Forty-five essential hypertensive patients without complication of cerebrovascular diseases(EH), 33 EH patients with cerebral hemorrhage(EH-CH), 73 EH patients with cerebral infarction(EH-CI), 60 healthy controls were genotyped for the A1166C variation at the 3′-untranslated region of AT1R gene by PCR/DdeⅠrestriction endonuclease digestion. Results:① For A1166C locus of AT1R gene, distributions of genotypes frequencies of EH and EH-CH group were significantly different from healthy controls(P 0.05). The frequencies of C in EH and EH-CH group were significantly higher than those in healthy controls(0.29 vs 0.17, P 0.05; 0.33 vs 0.17, P 0.01 respectively), but there was no significant difference in the frequencies of genotypes and C allele between EH and EH-CH group. ② No significant differences were found in the frequencies of genotypes and C allele as comparing EH, healthy controls with EH-CI group. ③Logistic regression analysis showed the polymorphism of AT1R gene was one of the independent risk factors for EH(P 0.05, OR = 0.44), but not for EH-CH.④The correlative analysis showed a positive correlation between the polymorphisms of AT1R gene and systolic blood pressure as well as diastolic blood pressure in patients with essential hypertension complicated with cerebrovascular diseases(r= 0.23 and 0.25 respectiveres, P 0.05). Conclusion: By increasing blood pressure, the A1166C allele of AT1R gene may contribute to the occurrence of EH-CH.