Clinical Study of Yiqi-huoxue and Huatan Formula on Inflammation Reactivation in Patients with Stable Coronary Heart Disease

Objective To observe the effect of Yiqi-huoxue and Huatan formula on inflammation reactivation in stable coronary heart disease(CHD).Methods 60 cases with stable CHD were randomly divided into the control group(30 cases,treated with routine therapy)and study group(30 cases,treated with routine therapy plus Yiqi-huoxue and Huatan formula).Duration was one month.Results There was no significant difference of concentration of CD40L before and after treatment in the control and study groups(P0.05).There was a significant difference in concentration of matrix metalloproteinase-9(MMP-9)before and after treatment in the control and study groups(P0.05).There were significant changes of CD40L and MMP-9 in the study group than in the control group(P0.05).Conclusion Yiqi-huoxue and Huatan formula can decrease serum concentration of CD40L and MMP-9,and inhibit initiation and development of inflammation reactivation,furthermore stable atherosclerotic plaque and reduce coronary events.