Effects of Combination Therapy of Probucol and Atorvastatin on Adjusting Inflammatory Factors in Spontaneously Hypertensive Rat with High Lipids Diet

Objective:To evaluate the effects of combination therapy of probucol and atorvastatin on adjusting inflammatory factors in spontaneously hypertensive rat (SHR) with high lipids diet. Methods:92 SHRs were randomly divided into 5 groups. Group C was treated with normal diet and normal saline. Group M,Group A,Group P and Group P + A were all treated with high lipids diet. At the same time,group M,group P,group A,group P + A were administrated with normal saline,probucol (150 mg. kg-1. d-1),atorvastatin (10 mg. kg-1. d-1),and probucol (150 mg. kg-1. d-1) plus atorvastatin (10 mg. kg-1. d-1),respectively. After 8 weeks treatment,all rats were killed. The serum levels of TC,TG,LDL-C,IL-6,TNF-α and hs-CRP were measured respectively before and after the experiment. All the above indexes were compared intra-groups and inter-groups. Results:Serum levels of TC,LDL-C in high lipids diet group (especially in group M) were obviously higher than baseline data (P 0.01),but serum levels of TG decreased. Serum levels of TC and LDL-C in group P,group A and group P + A were dramatically lower than that of group M (P 0.01),especially in group P + A. Serum levels of TG in group P + A and group A were lower than that of group M (P 0.01). Serum levels of IL-6,TNF-α and hs-CRP in group M obviously higher than that of group C and baseline data (P 0.01),and the inflammatory factors in group P,group A,especially group P + A were obviously lower than that of group M (P 0.01). Conclusion:High lipids diet may lead to the disorder of serum lipids and inflammatory factors. Combination therapy of probucol and atorvastatin can strengthen the effects on adjusting lipids and decrease the levels of inflammatory factors,and the effects of combination therapy are stronger than that of monotherapy.