The Hepatic Effects of Combination Therapy of Probucol and Atorvastatin in Spontaneously Hypertensive Rats with High Lipids Diet

Aim To evaluate the hepatic security of combination therapy of probucol and atorvastatin. Methods 92 spontaneously hypertensive rats were randomized into 5 groups:control group fed with normal diet,High lipids group,atorvastatin group,probucol group and combination therapy group all fed with high lipids diet. At the same time,probucol group [probucol 150 mg/(kg·d)],atorvastatin group [atorvastatin 10 mg/(kg·d)],and combination therapy group [probucol plus atorvastatin] were administrated drugs. After 8 weeks,all rats were killed. Serum TC,TG,LDLC,hs-CRP and ALT,AST levels were measured after experiment. At last liver pathological sections were observed on fatty degeneration and inflammation degree. Above indexes were compared inter-groups. Results ①Serum TC and LDL-C levels in every groups with high lipids diet were higher than control group(P0.01). Combination therapy group were obviously lower than probucol group(P0.01)and atorvastatin group(P0.01). ② Serum hs-CRP,ALT and AST levels in high lipids group were obviously higher than control group(P0.01),and combination therapy group were obviously lower than high lipids group and atorvastatin group(P0.01). ③ Every group with high lipids diet had fatty degeneration,and the degrees of fatty degeneration in high lipids group were severe,yet in combination therapy group were better than atorvastatin group and probucol group(P0.05). ④The scores of inflammation degree in combination therapy group were lower than high lipids group and atorvastatin group (P0.01). Conclusion ① High lipids diet may lead to the disorder of serum lipids and inflammatory factors,the damage of hepatic function,even hepatocyte fatty degeneration and necrosis. ② Combination therapy of probucol and atorvastatin may lighten the disorder of serum lipids and inflammatory factors,and decrease obvious hepatocyte fatty degeneration and necrosis degree caused by high lipids diet,and the effects were better than that of monotherapy. ③ Combination therapy may decrease obviously the damage of hepatic function caused by high lipids diet,even reduce the hepatic negative effects of atorvastatin.