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Significance of Cystatin C expression in type 2 diabetes

Changjun Hu

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Abstract

Objective: To investigate the expression of serum Cystatin C and its significance in type 2 diabetic mellitus patients. Methods:53 type 2 diabetic patients in hospital were divided into three groups: normoal buminuria group, microalbuminuria group, overalbuminuria group. Serum Cystatin C , serum creatinine (Scr) and blood urea nitrogenBUNwere measured .At the same time, urinary albumin exceretion rate (UAER) were measured. Results:Along with the UAER gradually increasing, both Scr and Cystatin C graduallyincreasd. Compared with those of norrrmoalbuminuria group, in microalbuminuria group, serum Cystatin C level increased significantly; in Overalbuminuria group, both BUN and Scr level increased significantly, while serum Cystatin C level increased more significantly. Conclusion:Serum Cystatin C is a more sensitive parameter than Scr to diagnose early diabetic nephropathy in type 2 diabetic mellitus patients.

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What this paper is about

Objective: To investigate the expression of serum Cystatin C and its significance in type 2 diabetic mellitus patients. Methods:53 type 2 diabetic patients in hospital were divided into three groups: normoal buminuria group, microalbuminuria group, overalbuminuria group. Serum Cystatin C , serum creatinine (Scr) and blood urea nitrogenBUNwere measured .At the same time, urinary albumin exceretion rate (UAER) were measured. Results:Along with the UAER gradually increasing, both Scr and Cystatin C graduallyincreasd. Compared with those of norrrmoalbuminuria group, in microalbuminuria group, serum Cystatin C level increased significantly; in Overalbuminuria group, both BUN and Scr level increased significantly, while serum Cystatin C level increased more significantly. Conclusion:Serum Cystatin C is a more sensitive parameter than Scr to diagnose early diabetic nephropathy in type 2 diabetic mellitus patients.

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Available abstract

Objective: To investigate the expression of serum Cystatin C and its significance in type 2 diabetic mellitus patients. Methods:53 type 2 diabetic patients in hospital were divided into three groups: normoal buminuria group, microalbuminuria group, overalbuminuria group. Serum Cystatin C , serum creatinine (Scr) and blood urea nitrogenBUNwere measured .At the same time, urinary albumin exceretion rate (UAER) were measured. Results:Along with the UAER gradually increasing, both Scr and Cystatin C graduallyincreasd. Compared with those of norrrmoalbuminuria group, in microalbuminuria group, serum Cystatin C level increased significantly; in Overalbuminuria group, both BUN and Scr level increased significantly, while serum Cystatin C level increased more significantly. Conclusion:Serum Cystatin C is a more sensitive parameter than Scr to diagnose early diabetic nephropathy in type 2 diabetic mellitus patients.

Key concepts: Microalbuminuria, Cystatin C, Diabetic nephropathy, Creatinine, Internal medicine, Medicine, Type 2 Diabetes Mellitus, Endocrinology

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