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2013•Chinese Journal of Trauma and Disability MedicineRequires access

Combination of Risperidone and Sertraline in Negative Symptoms of Schizophrenia

Jiang Yon

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Abstract

Objective: To explore the efficacies and safety of combination of risperidone and sertraline in negative symptoms of schizophrenia.Methods: 60 schizophrenics were randomly divided into treatment(n = 30,took risperidone combined with sertraline) and control group(n = 30,took risperidone) dose of risperidone was 2 ~ 6mg / d and that of sertraline 100 ~ 200mg / d for 8 weeks.Before and after treatment,efficacies and side effects were assessed using the Negative Syndrome Scale(NSS) and the Treatment Emergent Symptom Scale(TESS).Results: After treatment total score and factors,score of the NSS of both 2 groups obviously reduced and differences were significant(P 0.05).compared with the control group the total score of the NSS and factors',score of apathy poverty of thought abulia and interest blank obviously reduced in the treatment group and differences were significant(P 0.05).there was no difference in side effects between the 2 groups.Conclusion: combination of risperidone and sertraline is better than single risperidone in the treatment of negative symptoms of schizophrenia.

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Objective: To explore the efficacies and safety of combination of risperidone and sertraline in negative symptoms of schizophrenia.Methods: 60 schizophrenics were randomly divided into treatment(n = 30,took risperidone combined with sertraline) and control group(n = 30,took risperidone) dose of risperidone was 2 ~ 6mg / d and that of sertraline 100 ~ 200mg / d for 8 weeks.Before and after treatment,efficacies and side effects were assessed using the Negative Syndrome Scale(NSS) and the Treatment Emergent Symptom Scale(TESS).Results: After treatment total score and factors,score of the NSS of both 2 groups obviously reduced and differences were significant(P 0.05).compared with the control group the total score of the NSS and factors',score of apathy poverty of thought abulia and interest blank obviously reduced in the treatment group and differences were significant(P 0.05).there was no difference in side effects between the 2 groups.Conclusion: combination of risperidone and sertraline is better than single risperidone in the treatment of negative symptoms of schizophrenia.

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Available abstract

Objective: To explore the efficacies and safety of combination of risperidone and sertraline in negative symptoms of schizophrenia.Methods: 60 schizophrenics were randomly divided into treatment(n = 30,took risperidone combined with sertraline) and control group(n = 30,took risperidone) dose of risperidone was 2 ~ 6mg / d and that of sertraline 100 ~ 200mg / d for 8 weeks.Before and after treatment,efficacies and side effects were assessed using the Negative Syndrome Scale(NSS) and the Treatment Emergent Symptom Scale(TESS).Results: After treatment total score and factors,score of the NSS of both 2 groups obviously reduced and differences were significant(P 0.05).compared with the control group the total score of the NSS and factors',score of apathy poverty of thought abulia and interest blank obviously reduced in the treatment group and differences were significant(P 0.05).there was no difference in side effects between the 2 groups.Conclusion: combination of risperidone and sertraline is better than single risperidone in the treatment of negative symptoms of schizophrenia.

Key concepts: Risperidone, Sertraline, Medicine, Schizophrenia (object-oriented programming), Internal medicine, Apathy, Positive and Negative Syndrome Scale, Negative symptom

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