Combination of risperidone and small-dose paroxetine in negative symptoms of schizophrenia

Objective To explore the efficacies and safety of combination of risperidone and small-dose paroxetine in negative symptoms of schizophrenia.Methods 60 schizophrenics were randomly divided into treatment(n=30,took risperidone combined with paroxetine) and control group(n=30,took risperidone).Dose of risperidone was 2~8 mg/d and that of paroxetine 10~40 mg/d for 8 weeks.Before and after treatment,efficacies and side effects were assessed using the Negative Syndrome Scale(NSS) and the Treatment Emergent Symptom Scale(TESS).Results After treatment,total score and factors,scores of the NSS of both 2 groups obviously reduced and differences were significant(P0.05).Compared with the control group,the total score of the NSS and factors' score of apathy,poverty of thought,abulia and interest blank obviously reduced in the treatment group and differences were significant(P0.05).There was no difference in side effects between the 2 groups.Conclusion Combination of risperidone and small-dose paroxetine is better than single risperidone in the treatment of negative symptoms of schizophrenia.