ScholarLens Back to search
2009•Di-Si Junyi Daxue xuebaoRequires access

Effects of bFGF on expression of CREB in hippocampus and cortex during cerebral ischemia and reperfusion in rats

Chao Zeng

Open publisher page 0 citations

Abstract

AIM:To investigate the expression of cyclic AMP response element binding protein(CREB)in hippocampus and cortex after cerebral ischemia and reperfusion in rats and to explore the regulative effects of basic fibroblast growth factor(bFGF)on CREB in brain tissue and its mechanism.METHODS:The rat models of middle cerebral arteries occlusion(MCAO)were established with intraluminal filament blockade.The expression of CREB and apoptosis of neurons in hippocampus and cortex were detected with immunohistochemistry and TUNEL method respectively.RESULTS:The expression of CREB in hippocampus and cortex decreased after cerebral ischemia and reperfusion.In bFGF group,the expression of CREB increased while cell apoptosis decreased.CONCLUSION:bFGF depresses cell apoptosis,participates in the regulation of CREB expression in ischemic neurons and protects ischemic neurons.

About this research paper

What this paper is about

AIM:To investigate the expression of cyclic AMP response element binding protein(CREB)in hippocampus and cortex after cerebral ischemia and reperfusion in rats and to explore the regulative effects of basic fibroblast growth factor(bFGF)on CREB in brain tissue and its mechanism.METHODS:The rat models of middle cerebral arteries occlusion(MCAO)were established with intraluminal filament blockade.The expression of CREB and apoptosis of neurons in hippocampus and cortex were detected with immunohistochemistry and TUNEL method respectively.RESULTS:The expression of CREB in hippocampus and cortex decreased after cerebral ischemia and reperfusion.In bFGF group,the expression of CREB increased while cell apoptosis decreased.CONCLUSION:bFGF depresses cell apoptosis,participates in the regulation of CREB expression in ischemic neurons and protects ischemic neurons.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM:To investigate the expression of cyclic AMP response element binding protein(CREB)in hippocampus and cortex after cerebral ischemia and reperfusion in rats and to explore the regulative effects of basic fibroblast growth factor(bFGF)on CREB in brain tissue and its mechanism.METHODS:The rat models of middle cerebral arteries occlusion(MCAO)were established with intraluminal filament blockade.The expression of CREB and apoptosis of neurons in hippocampus and cortex were detected with immunohistochemistry and TUNEL method respectively.RESULTS:The expression of CREB in hippocampus and cortex decreased after cerebral ischemia and reperfusion.In bFGF group,the expression of CREB increased while cell apoptosis decreased.CONCLUSION:bFGF depresses cell apoptosis,participates in the regulation of CREB expression in ischemic neurons and protects ischemic neurons.

Key concepts: CREB, Hippocampus, Ischemia, Basic fibroblast growth factor, TUNEL assay, Apoptosis, Medicine, Cerebral cortex

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effects of bFGF on expression of CREB in hippocampus and cortex during cerebral ischemia and reperfusion in rats — Research Paper | ScholarLens