Effect of ligustrazine on ischemia-reperfusion injury of skeletal muscle in rabbits

Objective To explore the effect of ligustrazine on ischemia reperfusion injury of skeletal muscle in rabbits Methods 14 healthy adult rabbits were randomly divided into experimental and control groups (each of 7 rabbits).The ischemia reperfusion injury animal models were produced in rabbits limbs.When blood was reperfused after ischemia,ligustrazine solution was infused intravenously into rabbits of experimental group and normal saline injection into control group.The contents of malondialdehyde(MDA),lactic dehydrogenase(LDH)and superoxide dismutase(SOD)in serum were detected at the times of preischemia,post ischemia and post reperfusion.Skeletal muscle samples were obtained for light microscopy and electron microscopy.Results The contents of MDH and LDH in experimental group were significantly lower than that of control group(P0 01),but the content of SOD was obviously higher than that of control group(P0 01).In light microscope and electron microscope examinations,the skeletal muscle injury of experimental group was of a milder degree than that of control group.Conclusion Ligustrazine might have protective effect on skeletal muscle ischemia reperfusion injury.