Study on infection of human papillomavirus and cervical cancer in Xiushui region of Jiangxi

Objective:To investigate the infective situation of high risk human papillomavirus(HPV) in women,research the relationship between high risk HPV infection and cervical cancer,precancerous lesion.Methods:Hybrid capture-Ⅱ(HC-Ⅱ) method was used to detect high risk HPV DNA among married women aged 30～49 years old,multivariate non-conditional Logistic regression analysis was used to analyze the relationship between high risk HPV infection and cervical cancer,cervical intraepithelial neoplasia(CIN).Results:The total detection rate of high risk HPV DNA was 18.7%,increasing with aggravation of the disease compared with normal group(χ2=444.04,P0.001);there was no significant difference among different age groups(χ2=10.25,P0.001).Multivariate non-conditional Logistic regression analysis indicated that there was a correlation between HPV infection and cervical cancer,CIN(OR=121.1).Conclusion:High-risk HPV infection of female genital tract is a major risk factor of cervical cancer and CIN in Xiushui region,which indicates that the key point of prevention and treatment of cervical cancer should be focused on avoiding HPV infection,screening women for HPV infection and monitoring population infected by high-risk HPV.