Relationship between different types of human papillomavirus infections and cervical diseases

OBJECTIVE To elucidate the correlation between different types of human papillomavirus infection(HPV) and cervical disease.METHODS The cervical samples of 740 women were detected with flow-through hybridization and gene chip on HPV subtype and various cervical diseases were also analyzed.RESULTS Among the 740 women with HIV infections,21 types HPV were tested out,16/58/52 were the top three common subtypes.There were no differences in various cervical disease among different high-risk HPV infection(all P 0.05).But the low-risk HPV infection have significant difference with high-risk HPV infection in various cervical disease(all P0.05).Multiple logistic analysis showed HPV 16(OR=3.56,P0.01),58(OR=1.29,P0.05) would increase the risk of cervix cancer.CIN was classified into high grade and low grade lesion according to CINⅠ and CIN Ⅱ,CIN Ⅲ.By logistic regression analysis,HPV 6,11 had a certain correlation with CIN 0281,the OR were 6.99,5.92 respectively.CONCLUSIONS The risk of uterine cervix cancer infection is increased in women infected with high risk HPV subtypes.The infected with subtypes 16,18 of high risk HPV types are the important influential factors for the development of uterine cervix cancer.The low-risk subtypes of 6 and 11 of HPV infections have a certain correlation with CIN Ⅰ.