Relationship between prognosis and changes of serum cholinesterase, prealbumin and reactive protein C in children with sepsis

Objective To understand the characteristics of changes of the serum cholinesterase(CHE),prealbumin(PA),supersensitive reactive protein C (hsCRP) and reactive protein C (CRP) in the children with sepsis and their clinical significances, and to approach the changes and their effects on the prognosis of the sepsis in children.Methods From January, 2007 to February, 2009, 59 cases of sepsis in accord with diagnostic criteria underwent treatment of primary affection, respiratory sustentation, fluid anabiosis, vasoactive agent, anti-infection and symptomatic treatment, etc. And according to prognosis of disease, the cases were classified into one not-yet-recovered / expired group of 18 cases and one cured / survived group of 41. In all of the cases, on the day when into the groups and the third day, their serum CHE, hsCRP, CRP and indexes of liver function were detected. Serum PA of 49 cases was detected simultaneously,and a control group of 30 cases of the same age with pneumonia was set up.Results Compared with the levels of the serums CHE and PA of the cured / survived group, those of the not-yet-recovered / expired group with sepsis dropped remarkably (respectively P0.05 and P0.01) on the day entering the group and the third day, while the hsCRP and CRP rose remarkably(respectively P0.05 and P0.01).Compared with the serum CHE and PA of unimpaired children, those of the two groups both dropped remarkably (P0.01); hsCRP of the not-yet-recovered / expired group increased more than the control group (P0.01); CRP of the cured / survived group and the not-yet-recovered / expired increased more than the control group(both P0.05).Conclusion There are differently lower levels of serums CHE and PA and higher hsCRP and CRP in the impaired children with sepsis. Serums CHE, PA, hsCRP and CRP are indicative of the severity of the patient’s condition with sepsis, which are of referred value to the prognosis of the child with sepsis.