Serum Cholinesterase and Its Clinical Significance in Patients with Sepsis

Objective:To explore the changes of serum cholinesterase (ChE) and its clinical significance in patients with sepsis. Methods:Serum cholinesterase concentration, acute physiology and chronic health evaluation (APACHE) Ⅱscores were estimated in patients. The patients in this study were divided into the sepsis group and the non-sepsis group. The patients with sepsis were further divided into the death group and the survival group. The influence of altered serum ChE levels on prognosis was compared between the groups. Results:(1) Serum ChE was significantly lower in patients of sepsis group than that of control group (P 0.01). (2) In patients with sepsis, the serum ChE level was significantly lower in the death group compared with that of survival group (P 0.05). (3) In patients with sepsis the serum ChE levels were significantly negatively correlated with APACHE Ⅱ scores (r = -0.280, P 0.05), positively correlated with serum albumin and body mass index (r = 0.458 and 0.287,P 0.05). Conclusion: Serum ChE levels can be used to determine the prognosis and severity of illness in patients with sepsis.