Famotidine vs omeprazole in treating peptic ulcer with acute massive bleeding

AIM: To observe the therapeutic effect of intravenous large dosage famotidine and omeprazole in treating peptic ulcer with acute massive bleeding. METHODS: Sixty Patients endoscope shown peptic ulcer with active bleeding or recent bleeding signs, were divided into 2 groups at random. The famotidine group(M27,F3 ; age 46± s 17 a) received famotidine 40 mg in normal saline 20 mL iv, q 12h,for 3 d. The omeprazole group(M 26, F 4; age 45 ± 16 a) received omeprazole 40 mg, iv,q 12h,for 3 d. RESULTS: Definite hemostasis of 2 groups were all achieved. There were no adverse reactions in the famotidine group.Regarding to doses of blood transfusion,the days of hospitalization, and the days of turning stool occult blood tests to negative, there were no significant difference between 2 groups(P0.05). CONCLUSION: The therapeutic effect of intravenous large dosage famotidine on peptic ulcer with acute massive bleeding was similar to omeprazole.