Influence of lipid metabolic disorder and CRP level on patients with T2DM and CHD

Objective To observe the influence of lipid metabolic disorder and CRP level change on patients with T2DM and CHD. Methods Ninety- eight healthy people acted as control group( A),85 clinically diagnosed patients with T2DM served as observation group( B),55 clinically diagnosed patients with T2DM and CHD served as observation group( C). The concentrations of serum triglycerides( TG),total cholesterol( TC),low density lipoprotein cholesterol( LDL- C),high density lipoprotein cholesterol( HDL- C),serum apolipoprotein A1( ApoA1),apolipoprotein B( ApoB),ApoA1 / ApoB,HDL- C / LDL- C,and HDL- C / TC were determined with automatic biochemical analyzer,while the serum CRP levels were measured by immunoturbidimetry. Results Compare to the control group A,the levels of TG,TC,LDL- C,ApoB and CRP in observation groups( B,C) were significantly higher,while those of HDL- C,ApoA1,ApoA1 / ApoB,HDL- C / LDL- C,HDL- C / TC were significantly lower,the differences all had statistical significance. The levels of TG,TC,LDL- C,ApoB and CRP in C group were obviously higher than those in B group. Conclusion Obvious increase of TG,TC,LDL- C,ApoB and CRP levels and significant decrease of HDL- C,ApoA1,ApoA1 / ApoB,HDL- C / LDL- C,HDL- C / TC are found in simple T2DM patients and the patients with T2DM and CHD. Early diagnosis and timely treatment have close relationship with prognosis,the lipid metabolism disorder and CRP levels during the diagnosis and treatment process should be controlled to improve the therapeutic effect and prognosis,prevent or delay cardiovascular disease and other complications.