Regulation Effect of Soybean Saponins and Isoflavones on Blood Lipid in Mice

[Objective] The effects of soybean saponin and soybean isoflavone on blood lipids in mice were studied to provide the experimental basis for adjusting the blood lipid from the aspect of diet. [Method]72 Kunming mice( seven weeks old) were divided into six groups randomly,which was base group,high-fat group,high fat + low soybean saponin group( 25 mg /( kg·d)),high fat + high soybean saponin group( 50 mg /( kg·d)),high fat + low soybean isoflavone group 50 mg /( kg·d)),and high fat + high soybean isoflavone group( 100 mg /( kg·d)).They were gavaged for 4 weeks,then the eyes were removed to obtain the blood. The total cholesterol,triglyceride and low density lipoprotein and high density lipoprotein of mouse serum were determined. [Result]The level of total cholesterol,triglyceride,and low density lipoprotein in high-fat group was higher than that of the base group( P 0. 05),but the level of high density lipoprotein in high-fat group was lower than that of the base group( P 0. 05). Compared with the high-fat group,the level of the total cholesterol,and low density lipoprotein was decreased in soybean isoflavone of low and high dose group( P 0. 05),but the level of high density lipoprotein was increased( P 0. 05). The level of total cholesterol and triglyceride in low soybean saponin group was reduced( P 0. 05),but the level of high density lipoprotein was increased( P 0. 05). The level of triglyceride in high soybean saponin group was reduced.[Conclusion]Soybean isoflavone and soybean saponin had effects on reducing blood fat and preventing hyperlipidemia.