Relationship of serum homocysteine and cerebral infarction in patients with type 2 diabetes mellitus

Objective To investigate the relationship between serum homocysteine(Hcy) and cerebral infarction in patients with type 2 diabetes mellitus. Methods Fifty-eight patients with type 2 diabetes mellitus and cerebral infarction were included into the observation group, and 58 patients without cerebral infarction were included into the control group. The serum Hcy levels and carotid intima-media thickness(IMT) in the two groups were compared. Results The serum Hcy and carotid IMT in the observation group were significantly higher than those in the control group(P0.05). The serum Hcy levels in patients of type 2 diabetes mellitus and cerebral infarction with carotid IMT normal group, IMT thickening group and the plaque formation group were increased gradually, and the differences were of statistically significant(P0.05). Serum Hcy levels and carotid IMT was positively correlated(r=0.735, P0.05). Conclusion The carotid atherosclerosis is more serious in patients with type 2 diabetes mellitus and cerebral infarction than simple diabetes, and the Hcy is involved in the process of cerebral infarction.