Individualized Drug Therapy and Gene Polymorphism of CYP2C9

Cytochrome P450 protein 2C9(CYP2C9)is an essential human liver enzyme for drug metabolism,including 10%of routine drugs used in clinical practice and some crucial endogenous substances.CYP2CP has a high polymorphism as thirty single-base mutations of alleles have been identified until now.Functional mutations may alter the activity of CYP2C9 and the elimination rate of substance drugs.It is subject to the risk of drug adverse effects or toxicity.The genotyping of CYP2C9 prior to the administration helps to adjust the dose of substance drug based on the genotype of patient,improve the drug efficacy,and decrease the incidence of adverse effects in aiming to achieve individualized drug therapy.