Effect of Three Natural Medicine Compounds on Liver Fibrosis Induced by Carbon Tetrachloride in Rats

Objective:To study the effect of the compounds of Yulangsan polyose,Yulangsan flavones and Liuyueqing polyose against CCl4-induced liver fibrosis in rats and its mechanism.Method: Wistar rats were divided into two groups randomly:hepatic fibrosis model group and normal control group.The model group of rats with hepatic fibrosis was established by 2 mL·kg-1 intragastric administration(ig)of 50%CCl4 for 7 weeks.The rats in the normal control group were given normal saline(NS).Forty Wistar rats with hepatic fibrosis confirmed by the pathological inspection were divided into 4 groups randomly.All rats were treated with drugs or NS for four consecutive weeks by ig,once daily.Twenty-four hours after the last administration of drugs,all rats were killed,and the hepatic tissue were taken.The contents of Hyp,SOD,MDA in hepatic tissue were measured,the extent of liver fibrosis was observed by HE staining.Result: The contents of MDA(10.43±0.95) nmol·mg -1(P0.01),Hyp(0.26±0.05) μg·mg-1(P0.05)were decreased significantly and the contents of SOD(39.19±6.00) U·mg-1(P0.05)were increased significantly in high dose group.All drug groups could relieve liver Fibrosis.Conclusion: The compounds of Yulangsan polyose,Yulangsan flavones,Liuyueqing polyose can relieve liver fibrosis induced by CCl4.