Effect of Liuyueqing Polysaccharide on Liver Fibrosis Induced by Carbon Tetrachloride in Rats

Objective:To study the effect of the Liuyueqing polysaccharide against CCl4-induced liver fibrosis in rats and its mechanism.Method:SD rats were divided into two groups randomly: hepatic fibrosis model group and normal group.The model group of rats with hepatic fibrosis was established by 1 mL · kg-1 of 50% CCl4,ig,twice per week for continuous 7 weeks.The rats in the normal control group were given normal saline(NS).Sixty SD rats with hepatic fibrosis confirmed by the pathological inspection was randomly divided into LYQP(600,300,150 mg · kg-1) groups,colchicine(0.2 mg · kg-1) group and model group.All rats were treated with drugs or NS for four consecutive weeks by ig,once a day.The activity of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and glutathione synthesis(GSH-Px) in serum of rats and the content of hydroxyproline(Hyp) in hepatic tissue were determined.The extent of liver fibrosis was observed by Masson staining.Result:LYQP significantly decreased the activity of ALT and AST in rats with liver fibrosis.Compared with model control group,the content of Hyp in hepatic tissue was decreased significantly.The activity of GSH-Px was significantly increased.Masson staining showed that the collagen fibers in every treated group were less than model control group.Conclusion:Liuyueqing polysaccharide can relieve liver fibrosis induced by CCl4.