Application of Floxuridine-lipiodol in transcatheter arterial chemoembolization for huge hepatocellular carcinoma

Objective To explore the value of Floxuridine-lipiodol in the transcatheter arterial chemoembolization(TACE) for huge hepatocellular carcinoma(hHCC).Methods Thirty-two patients with hHCC received TACE with Floxuridine-lipiodol,then the feeding artery was blocked using gelatin sponge.One month later,CT and MR were performed to observe the tumor size and the level of AFP.The tumor size and AFP were compared before and 1 month after operation.Results All of the 32 patients received TACE successfully.A total of 98 times TACE were performed,each patient received 1 to 6 times TACE,with the average number of 3.1 times.The average volume of iodized oil was 16 ml.CT and MR proved that the lesion volume shrinked in 28 patients(87.50%),stayed stable in 3 patients(9.38%) and progressed in only 1 patient(3.12%).The level of AFP descended from(1235.26±76.18)μg/L to(429.31±21.67)μg/L(P0.05).Conclusion The effect of Floxuridine-lipiodol in TACE of hHCC is identified.TACE with Floxuridine-lipiodol is safe and feasible.