The utility of large dosage lipiodol treatment in huge primary hepatic carcinoma:a report of 47 cases

Objective To evaluate the effect and safety of large dosage iodized oil(lipiodol) treatment in huge primary hepatic carcinoma(PHC) via injecting from hepatic artery in each transarterial chemoembolization(TACE) case. Methods Fourty-seven cases with huge PHC received over 25 mL lipiodol injection in each TACE.Tumor maximal diameter,liver function,renal function,Child classification were recorded both before and after TACE.Angiography,lipiodol dosage and deposition in tumor and complications were also recorded. Results All patients were followed-up 2 and 4 weeks after TACE respectively.Tumor maximal diameter was significantly decreased [(13.02±0.52)cm vs(5.17±0.45)cm,P=0.000 0] after TACE.No major impairment of liver function and renal function was found in those patients after TACE.In angiographies,the main stem of portal wein was patency in all cases.The average dosage of lipiodol was 27.84 mL(range: 25-40 mL).Four weeks after CT,the rate of well lipiodol deposition was 85.1% in all cases.No severe complication happened in this series. Conclusions It is effective and safe for patients with huge mass PHC(without clear A-V-shunt,no portal vein main stem thrombi,Child A,nomal renal function) to receive over 25 mL lipiodol embolization.