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2004•Zhongguo jihua mianyiRequires access

Study on the Safety and Immunogenicity of China-made Inactivated Hepatitis A Vaccine,Healive~

Fang Cun-fu

Open publisher page 3 citations

Abstract

To investigate the safety and immunogenicity of a domestic inactivated hepatitis A vaccine,Healive ○R ,102 of 2-3 year old and 73 of 18-25 year old subjects were inoculated wit 250U/dose and 500U/dose respectively.The local and the systemic side effects were observed within 48h after vaccination,the seroconversion rate and geometric mean titer(GMT)of Healive○R antibody were evaluated six weeks after immunization.Results showed that the local and systemic reactions after immunization were mild and temporary.The positive seroconversion rate of HAV antidody was 94.52%,the GMT was 260.3mIU/ml.The domestic inactivated hepatitis A vaccine,Healive ○R ,has satisfactory safety and immunogenicity when applied to people.

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What this paper is about

To investigate the safety and immunogenicity of a domestic inactivated hepatitis A vaccine,Healive ○R ,102 of 2-3 year old and 73 of 18-25 year old subjects were inoculated wit 250U/dose and 500U/dose respectively.The local and the systemic side effects were observed within 48h after vaccination,the seroconversion rate and geometric mean titer(GMT)of Healive○R antibody were evaluated six weeks after immunization.Results showed that the local and systemic reactions after immunization were mild and temporary.The positive seroconversion rate of HAV antidody was 94.52%,the GMT was 260.3mIU/ml.The domestic inactivated hepatitis A vaccine,Healive ○R ,has satisfactory safety and immunogenicity when applied to people.

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Available abstract

To investigate the safety and immunogenicity of a domestic inactivated hepatitis A vaccine,Healive ○R ,102 of 2-3 year old and 73 of 18-25 year old subjects were inoculated wit 250U/dose and 500U/dose respectively.The local and the systemic side effects were observed within 48h after vaccination,the seroconversion rate and geometric mean titer(GMT)of Healive○R antibody were evaluated six weeks after immunization.Results showed that the local and systemic reactions after immunization were mild and temporary.The positive seroconversion rate of HAV antidody was 94.52%,the GMT was 260.3mIU/ml.The domestic inactivated hepatitis A vaccine,Healive ○R ,has satisfactory safety and immunogenicity when applied to people.

Key concepts: Immunogenicity, Seroconversion, Medicine, Hepatitis A vaccine, Immunization, Titer, Vaccination, Virology

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Study on the Safety and Immunogenicity of China-made Inactivated Hepatitis A Vaccine,Healive~ — Research Paper | ScholarLens