Effect of Edaravone on Cerebrospinal Fluid TNF-α/IL-6 in Acute Serious Cerebral Infarction

Objective:To study the effect of edaravone cerebrospinal fluid TNF-α and IL-6 with edaravone with acute serious cerebral infarction,and eveluate its protective mechanism.Methods:66 cases of cerebral hemorrhage in 72h were randomly divided into treatment group(35 cases)and control group(31 cases).TNF-α/IL-6 in cerebrospinal fluid were detcted by ELESA at pretherapy and after given treatment 10days.Neurological functional deficit scores were utilized for assessment before given treatment.On the 21th day after treatment,the patient was assessed again.and the efficacy was recorded.Results:After 10 days treatment,the level of TNF-α、IL-6 more transparently fall in treatment than that of control group,there were significant difference between the two groups(P0.01);On the 21th day after treatment,there were also significant differences between the two groups in terms of apparent effect rate(treated group:60%;control group:35%;χ_ 0.05 ~2=3.96,P0.05).Conclusion:Edaravone alleviate inflammation via cleaning free radical,so it may protect brain tissue and accelerate the recovery of neural function after serious cerebral infarction.