Optimization of the Extraction Technology for Huaqitongmai Granules with the Multiple Guidelines Grading Method

Objective To optimize the extraction technology for huaqitongmai granules(HTG). Methods An orthogonal test was adopted in the study.The rate of harvesting of the extract,the contents of scutellarin-7-0-glucuronide and tetrahydropalmatine were used as indices of appraisal.Data processing was carried out with the multiple guidelines grading method for optimizing the extraction condition. Results The optimized extraction technology for huaqitongmai granules was shown to be: a tenfold volume of 70 % alcohol should be added to 1 volume of the granules for 2 successive reflux extractions each of which lasting 2 h. Conclusion The optimized extraction technology was rational and the extraction rate of the active principles was high.