2006•Journal of Analytical ScienceRequires access

Simultaneous Determination of Rosmarinic Acid,Caffeic Acid and Ferulic Acid in Water-soluble Extract of Rosemary by LC/MS/MS

Yin Dong-hong

Abstract

A rapid LC/MS/MS method was developed for the simultaneous determination of rosmarinic acid,caffeic acid and ferulic acid.The mobile phase of HPLC was methanol-0.1% ammonium acetate aqueous solution.As to MS/MS,multi-reaction monitoring(MRM) scan was employed,and a complete analysis can finished in three minutes.The calibration curves for three analytes were linear in the range from 5 ng\5mL~(-1) to 500 ng\5mL~(-1).The developed method was rapid,accurate,robust and convenient,and it was applied to the measurement of rosmarinic acid,caffeic acid and ferulic acid concentrations in water-soluble extract of rosemary with satisfactory results.

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Key concepts: Rosmarinic acid, Chemistry, Caffeic acid, Chromatography, Ferulic acid, Ammonium acetate, High-performance liquid chromatography, Calibration curve