Study on curative effect of domestic Carboprost Tromethamine on preventing postoperative hemorrhage of high risk pregnant women with cesarean section

Objective To evaluate the curative effect and safety of domestic Carboprost Tromethamine (trade name: An Lie ke) on preventing intraoperative hemorrhage and postoperative hemorrhage of high risk pregnant women with cesarean section. Methods Three hundred and sixty pregnant women, who were admitted into 9 hospitals of Guangdong province from March to December 2011, had cesarean section due to bleeding high risk factors. According to the oxytocic drugs injected in the uterine body after delivery, 360 pregnant women were divided into 3 groups: group A (only injected oxytocin), group B (injected oxytocin plus Carboprost Tromethamine) and group C (only injected Carboprost Tromethamine). There were 120 patients in each group. The amount of bleeding was observed during operation, 2 hours after operation and 24 hours after operation, respectively. The amount of bleeding in each observation time and oxytocic drug side effects of the 3 groups were compared. Results In group B, the amount of bleeding were (331.4±209.7)ml, (421.8±239.2)ml and (593.6±242.3)ml during operation, 2 hours after operation and 24 hours after operation, respectively, which were significantly less than those in group A[(417.3±235.2)ml, (613.4±301.9)ml and (685.7±296.1)ml] (P 0.05). Totally, 42 cases of 360 cases were postpartum hemorrhage, which incidence rate was 11.7%. The incidence rate of postpartum hemorrhage in group A (18.3%, 22/120) was significantly higher than that in group B(7.5%, 9/120) and group C(9.2%, 11/120), ( χ2=6.145 and 3.596, P value 0.05). Conclusions Domestic Carboprost Tromethamine was effective and safe for high risk pregnant women with cesarean section to prevent intraoperative hemorrhage and postoperative hemorrhage. But the side effects need to be closely observed. Key words: Carboprost Tromethamine; Cesarean section; Postpartum hemorrhage; Treatment outcome