Effect of Resveratrol on Oxidative Damage Induced by D-galactose in Senile Mice

Objective To investigate the neutralization effect of resveratrol on oxidative damage induced by D-galactose in aged mice.Methods The senile model mice,were established by subcutaneous injection of 5% D-galactose at the nape,and adminstrated with resveratrol(15, 30 mg/kg) by oral gavage for 30 d.The lipofuscin(LF) and nitric oxide(NO) contents in brain,malondialdehyde(MDA) level,superoxide dismutase(SOD) and GSH-Px activities in serum and brain were detected by biochemistry method.Results In serum and brain of senile mice,the contents of NO and MDA increased,the activities of SOD and GSH-Px decrease.In addition,the LF in brain also elevated.Resveratrol administration of 15,30 mg/kg showed different degrees of antagonistic effect on the increase of MDA and NO levels,elevated the SOD and GSH-Px activities in serum and brain,decrease LF level in brain.Conclusion Resveratrol may postpone senility by eliminating oxygen free radicals and antilipoperoxidation.