[Antagonizing effect of resveratrol on the lipid peroxidative damage induced by lead in mice].

OBJECTIVE: To explore the antagonizing effect of resveratrol on the lipid peroxidation and antioxidant enzymes induced by lead in mice's liver and kidney. METHODS: The lead poisoning mice model was established by drinking water, which contained lead acetate, 60 Kunming male mice were randomly divided into 6 groups: control group. The lead poisoning model group, three lead groups treated by the low, medium and high dose of resveratrol, 10 mice in each. The lead concentration and the content of MDA and activity of SOD, GSH-Px, CAT, and ORAC were measured in liver and kidney tissue and serum. RESULTS: Compared with poisoning model group, The activation of SOD, GSH-Px was increased in liver and kidney tissue of three lead groups treated with resveratrol. The activity of SOD, GSH-Px, CAT and the content of MDA were significantly different among the groups (P < 0.01). The antagonizing dose of resveratrol was 800 - 1 200 mg/kg, it can enhance enzymes activity. CONCLUSION: Resveratrol may improve antioxidant enzymes activity and reduce lipid peroxidation in mice treated with lead in mice.