The effects of panaxadiol saponins on morphology and haemodynamics in ventricular remodeling rats

Objective To study the effects of panaxadiol saponins(PDS) on morphology and haemodynamics in ventricular remodeling rats.Methods The ventricular remodeling model was induced by myocardial infarction in rats of left anterior descending coronary occulusion.The Wistar rats were divided into sham,remodeling model,PDS and captopril groups.The rats in sham and remodeling model groups were treated with normal sodium(2 ml·kg-1·d-1,i.p).The PDS group was treated with PDS(50 mg·kg-1·d-1,i.p).The captopril group was treated with captopril(100 mg·kg-1·d-1,i.g).After 4 weeks,morphological parameters,hemodynamic changes,histopathologic parameters were determined in rats.Results After treated by PDS,left ventricular absolute weight and cardiac coefficient were decreased significantly,the mean arterial blood pressure(MAP) and the maximum left ventricular pressure rising and dropping rates(±dp/dtmax) were increased significantly,then the left ventricular end diastolic pressure(LVEDP) was reduced significantly.In addition,PDS also alleviated pathological injuries in ventricular remodeling rats.Conclusions PDS has protective effect on ventricular remodeling after myocardial infarction in rats.