Expression and its significance of G protein-coupled receptor 56 in laryngeal carcinoma

Objective To investigate the role of GPR56 in the development of laryngeal carcinoma. Methods The expression of GPR56 in 54 cases of glottic laryngeal carcinoma and 23 cases of normal glottic laryngeal tissues was detected by immunohistochemistry, and the relationship between GPR56 and the pathology charateristics of laryngeal carcinoma were also analyzed. Results The expression IOD of GPR56 in the laryngeal carcinoma group of 4806.0(1414.1, 1 3257.0) was significantly higher than that in the normal group of 428.7(26.4, 3266.3)(Z =-4.936, P = 0.000). In the laryngeal carcinoma group, the expression of GPR56 was closely related to histological grade, clinical stage and cervi cal lymph node metastasis(P 0.05). Conclusion High expression of GPR56 may contribute to the occurrence of laryngeal carcinoma. GPR56 specifical ligand is expected to become a new drug for the treatment for laryngeal carcinoma.