The Survivin Gene Expression of Elderly Patients with Leukemia and Clinical Significance

Objective To investigate the survivin gene expression in leukemia cells of elderly patients with leukemia,and analysis the factors of prognostic.Methods 32 patients with different stages of acute leukemia(AL)and 5 patients with chronic lymphocytic leukemia were divided into observation group,10 healthy people were divided into control group.The expression of survivin mRNA in leukemia cells was detected by RT-PCR.Results The expression of Survivin mRNA was 71.87% in acute leukemia(AL)cells,the expression of Survivin mRNA was 71.42% in acute lymphoblastic leukemia(ALL)cells,and the expression of Survivin mRNA was 76% in acute non-lymphocytic leukemia(ANLL)cells,the differences had no statistical significance,but the expression of Survivin mRNA were higher than the control group(χ2 = 5.90,6.81,P0.05).The expression of Survivin mRNA was 78.01% and 84.15% in leukemia cells of newly diagnosed and relapsed acute leukemia patients,significantly higher than the control group(χ2=12.61,9.23,P0.05).Leukemia cells without Survivin expression in Elderly patients with chronic lymphocytic leukemia.Conclusion The incidence and development of acute leukemia may be closely related to overexpression of Survivin gene.