The Diagnostic Implications of Cardiac Troponin I (cTnI), Myoglobin (Mb) and Creatine Kinase Isoenzyme (CK-MB) in Patients with Acute Myocardial Infarction (AMI)

Objective: To investigate the diagnostic implications of cardiac troponin I (cTnI), myoglobin (Mb) and creatine kinase isoenzyme (CK-MB) in patients with acute myocardial infarction (AMI). Methods: The serum concentrations of cTnI, Mb and CK-MB were determined in 46 patients with acute chest pain in the emergency department with the Biosite Triage Meter Plus. At the same time, the clinical symptoms and the development of the ECG abnormality were analyzed. Results: The sensitivity of AMI diagnosis:0～3 h, cTnI and CK-MB is 29.4%, Mb, 47.1%; 4～6 h, cTnI, 80%; CK-MB and Mb 100.0%. The specificity of AMI diagnosis: 0～3 h, 4～6h cTnI and CK-MB is 100%; Mb:0～3 h,58.8%; 4～6 h,40.0%; 12 h,33.3%. The sensitivity and specificity of cTnI, Mb and CK-MB in combination is:0～3 h, 35.3%, 86.3%; 4～6 h, 93.3%, 80.0%; 12 h, 100.0%, 77.8%. Conclusions: The bedside measurement of cTnI, Mb and CK-MB in combination is rapid and simple in the clinical utilization. It is useful for the early diagnosis and differentiation of AMI, providing the evidence for the treatment of AMI exactly and promptly.