The Role of Monitoring Concentration of Troponin I (cTnI), Creatine Kinase Isoenzyme MB(CK-MB), Myoglobin (Mb) on The Diagnosis of Acute Myocardial Infarction (AMI)

Objective Investigate the role of monitoring serum concentration of cardiac troponin I(cTnI),creative kinase isoenzyme MB(CK-MB) and myoglobin(Mb) on the diagnosis of Acute Myocardial Infarction(AMI).Methods Detect serum concentration of cTnI,CK-MB and Mb from 45 cases of AMI patients using electrochemical luminescence at five different timepoints.And another 45 cases of healthy controls were examined.Analyze cTnI,CKMB and Mb concentration by variance analysis and ROC curve,and discuss the diagnostic value.Results The serum concentrations of cTnI,CK-MB in AMI patients were significantly higher than control at all 5 different timepoints after onset of chest pain.The serum concentration of Mb in AMI patients was significantly higher than control at 0-6h,12h,24h after chest pain.And specificity,sensitivity,accuracy,positive predictive value(PPV) and negative predictive value(NPV) of cTnI,CK-MB were significantly higher than Mb on the diagnosis of AMI.Conclusion Combined detecting serum concentration dynamic changes of cTnI and CK-MB had significant value and high accuracy on early diagnosis of AMI,which help to improve the prognosis of patients.