Diagnosis Value of ~(99m)Tc-MIBI-SPECT and CT Fusion Imaging in Solitary Pulmonary Nodules

Objective To investigate the diagnosis of value99mTc-MIBI SPECT and CT fusion imaging in the differential solitary pulmonary nodule( SPN). Methods Thirty-nine patients with SPN underwent99mTc-MIBI-SPECT and positioning CT fusion imaging, and the imaging results carried on the qualitative and semi-quantitative analysis. The diagnostic value of the imaging method for SPN was judged according to the results of the final diagnosis. Results Of 39 cases with SPN,13 cases were malignant and 26 cases were benign. The diagnostic sensitivity, specificity, accuracy, negative predictive value and positive predictive value of99mTc-MIBI-SPECT positioning CT fusion imaging qualitative analysis in benign and malignant SPN was 92.31%(12/13),88.46%(23/26),89.74%(35/39),80%(12/15) and 95.83%(23/24),respectively. Receiver operating characteristic(ROC) curve analysis showed: using99mTc-MIBI early uptake ratio(EUR) ≥ 1.474 as the critical value for identification the benign and malignant SPN,the sensitivity and specificity was 100% and76.90%, respectively; using99mTc-MIBI delayed uptake ratio(DUR) ≥ 1.38 as the critical value, the sensitivity and specificity was 100% and 76.90%. Conclusion The method of99mTc-MIBI-SPECT and positioning CT fusion imaging has a high clinical value in the differential diagnosis of SPN.