~(99m)Tc-MIBI SPECT/CT fusion imaging combined with oxygen intervention for differential diagnosis of solitary pulmonary nodules

Objective To explore the differential diagnostic value of 99mTc-MIBI SPECT/CT fusion imaging combined with oxygen intervention for solitary pulmonary nodule(SPN).Methods Thirty-four patients with SPN were enrolled.All patients absorbed oxygen before 99mTc-MIBI injection.The early and delayed SPECT/CT fusion imaging of the chest were performed 10 min and 2 h after 99mTc-MIBI injection,respectively.The early and delayed uptake ratios(EUR and DUR) of benign and malignant SPN were compared.The efficiency of EUR and DUR in diagnosing SPN were analyzed with ROC curve.Results There were 10 patients with malignant SPN and 24 patients with benign SPN.The sensitivity,specificity,accuracy rate,positive predictive value and negative predictive value of qualitative analysis was 90.00%(9/10),87.50%(21/24),88.24%(30/34),75.00%(9/12) and 95.45%(21/22),respectively.In patients with malignant SPN,EUR was 2.13±0.62(95%CI 1.68—2.57),whereas that in patients with benign SPN was 1.31±0.42(95%CI 1.13—1.48).In patients with malignant SPN,DUR was 2.40±0.47(95%CI 2.07—2.74),whereas that in patients with benign SPN was 1.37±0.64(95%CI 1.09—1.64).EUR and DUR were significantly different between malignant and benign SPN(t=4.53,4.59;both P0.001).Semiquantitative analysis showed that when EUR≥1.50,the value of sensitivity and specificity was 90.00% and 79.20%,for DUR ≥1.47,the value of sensitivity and specificity was 100% and 79.20%,respectively.Conclusion 99mTc-MIBI SPECT/CT fusion imaging combined with oxygen intervention has good clinical value in differential diagnosis of malignant and benign SPN.