Changes on Neuro-specific Enolase of Serum and Cranial Computed Tomography in Neonates With Neonatal Hypoxic Ischemic Encephalopathy.

To study the role of neurospecific enolase(NSE) of serum and cranial computed tomography(CT) in diagnosis of neonatal hypoxic ischemic encephalopathy(HIE). Fifty neonates with HIE were divided into three groups by patient' condition:mild,moderate and severe group including 15,23 and 12 neonates respectively.Meanwhile,another 20 healthy neonates were taken as contrast.All samples of serum in neonates were obtained at postnatal day 3 and day 7.The levels of NSE in serum were estimated by enzyme linked immunoadsorbent assay.Neonates were checked by cranial CT in one week after being born. The levels of NSE in neonates with HIE especially those in the moderate and the severe group increased significantly in postnatal three days and then decreased gradually with improvement of patient' condition,which was consistent with clinical grade.The cranial CT of neonates in severe group was coincident with clinical grade but that in the mild and moderate group weren't completely consistent with it. [Conclusion] The assay of NSE in serum is an operative index to diagnose HIE in earlier period,verdict patient' condition and estimate patient' prognosis.The combination of cranial CT in one week and assay of NSE in serum can offer a good help to diagnosis and therapy of HIE.