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Alteration of T cell subsets in HIV/AIDS Patients by Flow Cytometer

Zhixiang Liu

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Abstract

Objective To study the immune status of HIV/AIDS patients by using flow cytometer (FCM ) to detect peripheral lymphocyte subset counts. Methods T cell subsets from 50 normal adults,12 AIDS patients,18 HIV infected persons were detected by flow cytometer. Results The HIV/AIDS patients' CD4 + cell counts were lower than those of normal controls. Especially, the AIDS patients' CD4 + counts were all below 200 cells/mm 3, but an obvious increasing of CD8 + cell percentage has been found in HIV/AIDS patients,The CD4 +/CD8 +ratio was significantly inversed. Conclusion The immunological status of HIV/AIDS Patients by Flow Cytometer might be considered as an important indicator in AIDS stage.

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What this paper is about

Objective To study the immune status of HIV/AIDS patients by using flow cytometer (FCM ) to detect peripheral lymphocyte subset counts. Methods T cell subsets from 50 normal adults,12 AIDS patients,18 HIV infected persons were detected by flow cytometer. Results The HIV/AIDS patients' CD4 + cell counts were lower than those of normal controls. Especially, the AIDS patients' CD4 + counts were all below 200 cells/mm 3, but an obvious increasing of CD8 + cell percentage has been found in HIV/AIDS patients,The CD4 +/CD8 +ratio was significantly inversed. Conclusion The immunological status of HIV/AIDS Patients by Flow Cytometer might be considered as an important indicator in AIDS stage.

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Available abstract

Objective To study the immune status of HIV/AIDS patients by using flow cytometer (FCM ) to detect peripheral lymphocyte subset counts. Methods T cell subsets from 50 normal adults,12 AIDS patients,18 HIV infected persons were detected by flow cytometer. Results The HIV/AIDS patients' CD4 + cell counts were lower than those of normal controls. Especially, the AIDS patients' CD4 + counts were all below 200 cells/mm 3, but an obvious increasing of CD8 + cell percentage has been found in HIV/AIDS patients,The CD4 +/CD8 +ratio was significantly inversed. Conclusion The immunological status of HIV/AIDS Patients by Flow Cytometer might be considered as an important indicator in AIDS stage.

Key concepts: CD8, CD4-CD8 Ratio, Medicine, Immune status, Human immunodeficiency virus (HIV), Immunology, Immune system, Lymphocyte subsets

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