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2002•Journal of Clinical Transfusion and Laboratory MedicineRequires access

Study of immunological status of HIV/AIDS patients by flow cytometer

Zhang Jianpin

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Abstract

Objective To study the immunological status of HIV/AIDS patients. Methods T cell subsets from 20 normal control subjects, 38 asympformatic HIV infected persons, 24 sympformatic HIV infected persons and 21 AIDS patients were detected by flow cytometer:four colors tru count (CD45 +,CD3 +,CD4 +,CD8 +),and the clinical stages were also analyzed. Results The numbers of CD4 + cell and the ratios of CD4 + to CD8 + in HIV infected persons and AIDS patients were less than normal control subjects significantly (P0.01) and were decreasing with development of different infectious periods, a remarkable difference between different infectious periods was also observed. Conclusion It suggested that the numbers of CD4 + cell and the ratios of CD4 + to CD8 + might be considered as important predictors of the HIV infectious stages.

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Objective To study the immunological status of HIV/AIDS patients. Methods T cell subsets from 20 normal control subjects, 38 asympformatic HIV infected persons, 24 sympformatic HIV infected persons and 21 AIDS patients were detected by flow cytometer:four colors tru count (CD45 +,CD3 +,CD4 +,CD8 +),and the clinical stages were also analyzed. Results The numbers of CD4 + cell and the ratios of CD4 + to CD8 + in HIV infected persons and AIDS patients were less than normal control subjects significantly (P0.01) and were decreasing with development of different infectious periods, a remarkable difference between different infectious periods was also observed. Conclusion It suggested that the numbers of CD4 + cell and the ratios of CD4 + to CD8 + might be considered as important predictors of the HIV infectious stages.

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Available abstract

Objective To study the immunological status of HIV/AIDS patients. Methods T cell subsets from 20 normal control subjects, 38 asympformatic HIV infected persons, 24 sympformatic HIV infected persons and 21 AIDS patients were detected by flow cytometer:four colors tru count (CD45 +,CD3 +,CD4 +,CD8 +),and the clinical stages were also analyzed. Results The numbers of CD4 + cell and the ratios of CD4 + to CD8 + in HIV infected persons and AIDS patients were less than normal control subjects significantly (P0.01) and were decreasing with development of different infectious periods, a remarkable difference between different infectious periods was also observed. Conclusion It suggested that the numbers of CD4 + cell and the ratios of CD4 + to CD8 + might be considered as important predictors of the HIV infectious stages.

Key concepts: CD8, Immunology, Human immunodeficiency virus (HIV), Medicine, CD3, Cd4 t cell, CD4-CD8 Ratio, T cell

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