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STUDY ON THE IN VITRO ACTIVITY OF MEZLOCILLIN/TAZOBACTAM AGAINST CLINICALLY ISOLATED 252 STRAINS OF BACTERIA

QU Ya-ping

Abstract

Objective To evaluat the in vitro antibacterial activity of mezlocillin/tazobactam against 252 strains of pathogens isolated from patients and compared with mezlocillin only.MethodsThe minimum inhibitory concentrations(MIC) of two β-lactams against 252 clinically isolated strains was detected with agar dilution method.ResultsThe results indicated that the in vitro antitacterial activity of mezlocillin/tazobactam(8∶1) was good.The MIC50 of mezlocillin/tazobactam(8∶1) was 1/128 of that of mezlocillin only,the MIC90 of mezlocillin/tazobactam(8∶1) was also 1/128 of that of mezlocillin only.ConclusionThe in vitro antibacterial activities of mezlocillin/tazobactam(8∶1) against clinically isolated 252 strains of bacteria are high.Mezlocillin/tazobactam(8∶1) is stable to β-lactamase and is an effective bactericidal agent.

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Key concepts: Mezlocillin, Tazobactam, Microbiology, Agar dilution, In vitro, Antibacterial activity, Minimum inhibitory concentration, Chemistry