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In Vitro Antibacterial Activity of Penicillins and β-lactamase Inhibitor

Xian Wang

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Abstract

Objective To compare the efficacy of three β-lactamase inhibitors and investigate in vitro anti-bacterial activity of penicillins/tazobactam against pathogens isolated from patients. Methods The minimum inhibitory concentrations(MIC) of the anti-bacterial agents against clinically isolated strains was detected by the agar dilution method. Results It was indicated that tazobactam showed the most powerful β-lactamase inhibition.The MIC50 of amoxicillin /tazobactam,azlocillin/tazobactam and mezlocillin/tazobactam against the common pathogens like Staphylococcus aureus,Staphylococcus epidermidis and E.coli was 93.75%,96.88%,93.75% lower than the single use,respectively. Conclusion The in vitro antibacterial activities of penicillins are significantly improved in combination with tazobactam.

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What this paper is about

Objective To compare the efficacy of three β-lactamase inhibitors and investigate in vitro anti-bacterial activity of penicillins/tazobactam against pathogens isolated from patients. Methods The minimum inhibitory concentrations(MIC) of the anti-bacterial agents against clinically isolated strains was detected by the agar dilution method. Results It was indicated that tazobactam showed the most powerful β-lactamase inhibition.The MIC50 of amoxicillin /tazobactam,azlocillin/tazobactam and mezlocillin/tazobactam against the common pathogens like Staphylococcus aureus,Staphylococcus epidermidis and E.coli was 93.75%,96.88%,93.75% lower than the single use,respectively. Conclusion The in vitro antibacterial activities of penicillins are significantly improved in combination with tazobactam.

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Available abstract

Objective To compare the efficacy of three β-lactamase inhibitors and investigate in vitro anti-bacterial activity of penicillins/tazobactam against pathogens isolated from patients. Methods The minimum inhibitory concentrations(MIC) of the anti-bacterial agents against clinically isolated strains was detected by the agar dilution method. Results It was indicated that tazobactam showed the most powerful β-lactamase inhibition.The MIC50 of amoxicillin /tazobactam,azlocillin/tazobactam and mezlocillin/tazobactam against the common pathogens like Staphylococcus aureus,Staphylococcus epidermidis and E.coli was 93.75%,96.88%,93.75% lower than the single use,respectively. Conclusion The in vitro antibacterial activities of penicillins are significantly improved in combination with tazobactam.

Key concepts: Tazobactam, Microbiology, Staphylococcus aureus, Beta-Lactamase Inhibitors, Mezlocillin, Minimum inhibitory concentration, Agar dilution, Azlocillin

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