Study of the Antimicrobial activity in vitro of Domestic Mezlocillin/Sulbactam and Other Three Antimicrobials

OBJECTIVE The antimicrobial activity in vitro of mezlocillin/sulbactam(MLBT),piperacillin/tazobactam(Tazocillin,TZXL),mezlocillin(MLXL) and ticarcillin/clavulanic acid(Timentin TMT) against 179 clinical isolates was studied.METHODS MICs were determined by agar dilution method.RESULTS The antimicrobial activity in vitro of MLBT against clinical bacteria was 1 2 times higher than that of MLXL.In vitro,MLBT has higher susceptibility than MLXL against Escherichia coli which have higher rate producing β lactamase,such as Enterobacter species,Acinetobacter species,et al.,and has higher susceptibility than TMT against Enterobacter and other G bacillus(P0.01).MLBT and TZXL have similar antibacterial spectrum and activity susceptible rate.MIC 50 of TZXL was 1 2 times lower than that of the MLBT,but there were no siginficant differences. CONCLUSIONS The antimicrobial spectrum and antimicrobial activity in vitro of MLBT were similar to that of TZXL.