Relationship of interleukin-6 gene -572C/G polymorphism with myocardial infarction and serum lipids

Objective To observe the frequency of interleukin-6(IL-6) gene -572C/G polymorphism and its relationship with myocardial infarction(MI) and serum lipids in Chinese Hans. Methods IL-6/gene-572C/G polymorphism was genotyped in 232 MI patients and 260 healthy adults by PCR-RFLP method. Results There were IL-6/gene-572 CC、CG and GG genotype. -572GG genotype and G allele were more frequent in patients than those in controls(P0.01).Compared with CC genotype, the odds ratio (OR) for MI was 1.68(95%CI:1.17-2.41,P0.01) for carriers of G allele, and OR was 1.53 and 4.87 for CG genotype and for GG genotype respectively. Meanwhile the level of triglyceride(TG) of G allele carriers was significantly higher than CC genotype in MI group. Conclusions IL-6/gene-572G allele may be a possible genetic susceptibility factor for MI in Chinese Hans population, and it can affect the level of TG in patients with MI.