The serum level of Interleukin-6 and its gene polymorphism in patients with acute myocardial infarction

Objective To investigate serum level of interleukin-6(IL-6) and the frequency of its gene -572 C/G polymorphism in patients with acute myocardial infarction(AMI) in Chinese Hans.Methods Serum IL-6 level and -572 C/G polymorphism were measured in 145 patients with AMI and 170 control subjects.IL-6 level was examined by ELISA method.-572 C/G polymorphism was genotyped by PCR-RFLP method.Results Serum IL-6 level in patients with AMI was significantly higher than that in control subjects (25.36 ±19.91 Vs 4.59±2.69,P 0.01,unit:pg/ml).-572 CC、CG and GG genotype frequency were 52.41%、41.38%、6.21% in AMI patients and 64.12%、34.70%、1.18% in control group,respectively.-572 CG+GG genotype and G allele were more frequent in patients than in controls(P0.05).Compared with CC genotype,the odds ratio for AMI was 1.62(95% CI:1.03～2.55,P0.05)for CG+GG genotype.There was no significant difference about serum level of IL-6 between different genotype groups(P0.05).Conclusion Serum level of IL-6 and frequency of -572 CG+GG genotype were higher in patients with AMI as compared with control subjects.IL-6 gene -572 C/G polymorphism may be a possible genetic susceptibility factor for AMI in Chinese Hans population.