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The Expression and Significance of MMP- 9 of Matrix Metalloproteinases in Gastric Cancer

Hong Pu

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Abstract

Objective:To observe the expression of MMP-9 in gastric cancer and to explore its clinical value in the occurrence, development of gastric cancer.Methods:The expressions of MMP-9 in gastric carcinoma tissues of 56 patients and normal gastric mucosa of 24 cases were detected by immunohistochemistry.Results:In 56 cases of primary gastric cancer,the positive rate of MMP-9 expression was 73.21%(41/56),far higher than that of the normal gastric mucosa(20.83%,5/24).The difference was significant(P0.01);There was a positive correlation between the expression of MMP-9 and the TNM staging,lymph node metastasis and serosal invasion and no correlation was observed between the expression of MMP-9 and differentiation of gastric cancer(P0.05). Conclusion:Matrix metalloproteinase MMP- 9 may be involved in the occurrence,development process,invasion and metastasis of gastric cancer.It can be used as an important tumor marker to judge the prognosis of gastric cancer.

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Objective:To observe the expression of MMP-9 in gastric cancer and to explore its clinical value in the occurrence, development of gastric cancer.Methods:The expressions of MMP-9 in gastric carcinoma tissues of 56 patients and normal gastric mucosa of 24 cases were detected by immunohistochemistry.Results:In 56 cases of primary gastric cancer,the positive rate of MMP-9 expression was 73.21%(41/56),far higher than that of the normal gastric mucosa(20.83%,5/24).The difference was significant(P0.01);There was a positive correlation between the expression of MMP-9 and the TNM staging,lymph node metastasis and serosal invasion and no correlation was observed between the expression of MMP-9 and differentiation of gastric cancer(P0.05). Conclusion:Matrix metalloproteinase MMP- 9 may be involved in the occurrence,development process,invasion and metastasis of gastric cancer.It can be used as an important tumor marker to judge the prognosis of gastric cancer.

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Available abstract

Objective:To observe the expression of MMP-9 in gastric cancer and to explore its clinical value in the occurrence, development of gastric cancer.Methods:The expressions of MMP-9 in gastric carcinoma tissues of 56 patients and normal gastric mucosa of 24 cases were detected by immunohistochemistry.Results:In 56 cases of primary gastric cancer,the positive rate of MMP-9 expression was 73.21%(41/56),far higher than that of the normal gastric mucosa(20.83%,5/24).The difference was significant(P0.01);There was a positive correlation between the expression of MMP-9 and the TNM staging,lymph node metastasis and serosal invasion and no correlation was observed between the expression of MMP-9 and differentiation of gastric cancer(P0.05). Conclusion:Matrix metalloproteinase MMP- 9 may be involved in the occurrence,development process,invasion and metastasis of gastric cancer.It can be used as an important tumor marker to judge the prognosis of gastric cancer.

Key concepts: Medicine, Matrix metalloproteinase, Cancer, Immunohistochemistry, Lymph node metastasis, Metastasis, Pathology, Gastric carcinoma

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