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2006•Zhonghua zhongliu fangzhi zazhiRequires access

Expression and clinical significane of matrix metalloproteinase-3 in colorectal carcinoma

Jingfen Wang

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Abstract

OBJECTIVE: To explore the expression of matrix metalloproteinase-3(MMP-3) and it's relation with clinicopathological parameters in colorectal adenoma and colorectal carcinoma. METHODS: The expression of MMP-3 was detected in 20 colorectal adenomas and 60 colorectal carcinomas by the immunohistochemical method. RESULTS: The positive expression rates of MMP-3 in 20 colorectal adenoma and 60 colorectal carcinomas were 10.0%(2/20) and 41.7%(25/60) (P=0.031) respectively. The positive expression of MMP-3 in colorectal carcinomas had positive correlation with lymph node metastasis (P=0.008), and negative correlation with 5 years survival rate(P=0.003).CONCLUSIONS: The up-regulation expression of colorectal carcinomol MMP-3 may be involved in carcinogenesis, progression, invasion and metastasis of colorecta carcinoma. Thus it is very important for predicting the prognosis in colorectal carcinoma.

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OBJECTIVE: To explore the expression of matrix metalloproteinase-3(MMP-3) and it's relation with clinicopathological parameters in colorectal adenoma and colorectal carcinoma. METHODS: The expression of MMP-3 was detected in 20 colorectal adenomas and 60 colorectal carcinomas by the immunohistochemical method. RESULTS: The positive expression rates of MMP-3 in 20 colorectal adenoma and 60 colorectal carcinomas were 10.0%(2/20) and 41.7%(25/60) (P=0.031) respectively. The positive expression of MMP-3 in colorectal carcinomas had positive correlation with lymph node metastasis (P=0.008), and negative correlation with 5 years survival rate(P=0.003).CONCLUSIONS: The up-regulation expression of colorectal carcinomol MMP-3 may be involved in carcinogenesis, progression, invasion and metastasis of colorecta carcinoma. Thus it is very important for predicting the prognosis in colorectal carcinoma.

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Available abstract

OBJECTIVE: To explore the expression of matrix metalloproteinase-3(MMP-3) and it's relation with clinicopathological parameters in colorectal adenoma and colorectal carcinoma. METHODS: The expression of MMP-3 was detected in 20 colorectal adenomas and 60 colorectal carcinomas by the immunohistochemical method. RESULTS: The positive expression rates of MMP-3 in 20 colorectal adenoma and 60 colorectal carcinomas were 10.0%(2/20) and 41.7%(25/60) (P=0.031) respectively. The positive expression of MMP-3 in colorectal carcinomas had positive correlation with lymph node metastasis (P=0.008), and negative correlation with 5 years survival rate(P=0.003).CONCLUSIONS: The up-regulation expression of colorectal carcinomol MMP-3 may be involved in carcinogenesis, progression, invasion and metastasis of colorecta carcinoma. Thus it is very important for predicting the prognosis in colorectal carcinoma.

Key concepts: Colorectal cancer, Medicine, Colorectal adenoma, Immunohistochemistry, Lymph node metastasis, Internal medicine, Metastasis, Matrix metalloproteinase

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