Clinical Therapeutic Effects of Edaravone Injection in the Treatment of Acute Cerebral Hemorrhage

Objective To study the clinical therapeutic effects of edaravone injection in the treatment of acute cerebral hemorrhage. Methods 50 patients with acute cerebral hemorrhage according with the diagnostic criteria were randomly divided into 2 equal groups: the trial group and control group.Osmotic diuretics,antihypertensives,antidiabetics,brain cell activators and remedies for symptomatic treatment in different doses were used in patients of the control group according to the extent of the cerebral hemorrhage.On the basis of these managements,patients of the trial group were given each 30 mg of edaravone dissolved in 250 mL of 0.9% sodium chloride solution administered by intravenous instillation b.i.d.for 14 consecutive days.Scoring of the nervous function defect and assessment of the therapeutic effectiveness in patients of both groups were carried out 7,14 and 28 days,respectively,after the termination of the treatment course with the use of the Chinese Stroke Scale(CSS). Results In patients of the trial group,the CSS scoring of 19.6±8.7 before the treatment fell to a low value of 11.8±4.6((P0.01))28 days after the termination of the treatment.In patients of the control group,the pre-treatment CSS scoring of 20.5±9.6 dropped to a post-treatment value of 15.4±6.3(P0.05) 28 days after the termination of the treatment.The post-treatment CSS scoring in patients of the trial group was significantly lower than that in patients of the control group(P0.05).No major adverse reactions were encountered in patients of the trial group. Conclusion Edaravone was shown to effectively improve the nervous function in patients with acute cerebral hemorrhage.