ScholarLens Back to search
2000•Medical Laboratory SciencesRequires access

The Relationship of Point Mutation of Site 1896 of HBV Precore with Liver Diseases

Yang Chun

Open publisher page 0 citations

Abstract

Objective To investigate the relationship of the site 1896 point mutation of HBV precore with chronic hepatitis,active cirrhosis and hepatocellular carcinoma(HCC).Methods According to the precore region of HBV.Polymerase chain reaction (PCR) is used to investigate the point mutation of site 1896 of HBV(G→A).Results Through the examination of the HBV site 1896 in the serum in these patients,find that the point mutation exists in all these types of patients,and the positive rates are 47 22%(17/36),53 33%(9/15)and 26 08%(6/23)respectively.Conclusion The positive rates of HBV site 1896 point mutation are relatively higher in CAH and ALH than that in HCC patients.which indicates that the mutation of HBV has relationship with the long term of HBV infection and the deterioration of liver damage by HBV.And the mutation of HBV is one of the inducing factors of HCC,but not the major factor.

About this research paper

What this paper is about

Objective To investigate the relationship of the site 1896 point mutation of HBV precore with chronic hepatitis,active cirrhosis and hepatocellular carcinoma(HCC).Methods According to the precore region of HBV.Polymerase chain reaction (PCR) is used to investigate the point mutation of site 1896 of HBV(G→A).Results Through the examination of the HBV site 1896 in the serum in these patients,find that the point mutation exists in all these types of patients,and the positive rates are 47 22%(17/36),53 33%(9/15)and 26 08%(6/23)respectively.Conclusion The positive rates of HBV site 1896 point mutation are relatively higher in CAH and ALH than that in HCC patients.which indicates that the mutation of HBV has relationship with the long term of HBV infection and the deterioration of liver damage by HBV.And the mutation of HBV is one of the inducing factors of HCC,but not the major factor.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To investigate the relationship of the site 1896 point mutation of HBV precore with chronic hepatitis,active cirrhosis and hepatocellular carcinoma(HCC).Methods According to the precore region of HBV.Polymerase chain reaction (PCR) is used to investigate the point mutation of site 1896 of HBV(G→A).Results Through the examination of the HBV site 1896 in the serum in these patients,find that the point mutation exists in all these types of patients,and the positive rates are 47 22%(17/36),53 33%(9/15)and 26 08%(6/23)respectively.Conclusion The positive rates of HBV site 1896 point mutation are relatively higher in CAH and ALH than that in HCC patients.which indicates that the mutation of HBV has relationship with the long term of HBV infection and the deterioration of liver damage by HBV.And the mutation of HBV is one of the inducing factors of HCC,but not the major factor.

Key concepts: Point mutation, Mutation, Hepatocellular carcinoma, Cirrhosis, Medicine, Virology, Hepatitis B virus, Hepatitis B

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The Relationship of Point Mutation of Site 1896 of HBV Precore with Liver Diseases — Research Paper | ScholarLens